abstract：:Inhalation is a potentially viable route of administration for numerous agents. In diabetes mellitus, the need for frequent injections to achieve ideal glycemic control remains a significant limitation for initiating and complying with insulin therapy in a large number of patients. To overcome this barrier, inhaled in...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zarogoulidis P,Papanas N,Kouliatsis G,Spyratos D,Zarogoulidis K,Maltezos E

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The site of deposition in the respiratory tract for aerosolized, inhaled therapeutic drugs depends on both the particles' aerodynamic size and the patient's breathing pattern. METHODS:In 21 healthy subjects with normal lung function, we evaluated an extremely slow inhalation of a large 9.5-μm MMAD particle ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Zeman KL,Wu J,Bennett WD

更新日期：2010-12-01 00:00:00

abstract：:Significant advances have been made in the last 50 years in developing safe and efficacious aerosol formulations for pulmonary delivery. The key to future innovation may lie at the interface between biology and particle engineering. Improved understanding of biological processes including particle clearance, cellular ...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Weers JG,Bell J,Chan HK,Cipolla D,Dunbar C,Hickey AJ,Smith IJ

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Programmed cell death 4 (PDCD4), a protein that binds to eukaryotic initiation factor 4A (eIF4A), inhibits the initiation of translation. Although a number of tumor suppressors target transcription, Pdcd4 is the first suppressor targeting protein translation, and has also been suggested to function as a tumo...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Hwang SK,Minai-Tehrani A,Lim HT,Shin JY,An GH,Lee KH,Park KR,Kim YS,Beck GR Jr,Yang HS,Cho MH

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Inhaled alpha1-antitrypsin (AAT) is being developed for treatment of cystic fibrosis to protect the lungs from excessive free elastase. High drug costs mandate a very efficient aerosol system to deliver a high payload to the airways. The I-neb Adaptive Aerosol Delivery (AAD) System is a portable, electronic,...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Geller DE,Kesser KC

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:The Respimat Soft Mist Inhaler is reported to generate an aerosol with low spray momentum and a small droplet size. However, the transport characteristics of the Respimat aerosol are not well understood. The objective of this study was to characterize the transport and deposition of an aerosol emitted from t...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Worth Longest P,Hindle M

更新日期：2009-06-01 00:00:00

abstract：:Antibiotic-resistant bacterial infections have renewed interest in finding substitute methods of treatment. The purpose of the present in vitro study was to investigate the possibility of respiratory delivery of a Burkholderia cepacia complex (BCC) bacteriophage by nebulized aerosol administration. Bacteriophages in i...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Golshahi L,Seed KD,Dennis JJ,Finlay WH

更新日期：2008-12-01 00:00:00

abstract：:Flexhaler is a multiple-dose, inspiratory flow-driven dry powder inhaler that is a newer version of Turbuhaler, and is identical to the Symbicort Turbuhaler. Sustained performance is of the utmost importance to ensure consistent drug delivery throughout the lifespan of the inhaler. We report functionality testing resu...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Lööf T,Elfman P,Ström P,Törngren A,Borgström L

更新日期：2008-12-01 00:00:00

abstract：:The present study aimed at assessing the pharmacokinetics (PK) and safety pharmacodynamics (PD) of 24 microg formoterol delivered via a Novolizer and via an Aerolizer in healthy subjects. This was a randomized, open-label, crossover study. Beside PK, serum potassium, and glucose profiles, vital signs, and ECG were rec...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Petzold U,Kremer HJ,Nguyen DT,Munzel U,Dietrich H,Maus J

更新日期：2008-09-01 00:00:00

abstract：:Exhaled breath condensate (EBC) consists mainly of water, but also contains semivolatile and nonvolatile compounds. The aim of this study was to develop a system in which two condensers are simultaneously used in series to clarify the mechanisms of EBC condensation. Two aliquots of EBC (EBC1 and EBC2) were collected f...

journal_title：Journal of aerosol medicine and pulmonary drug delivery

authors： Corradi M,Goldoni M,Caglieri A,Folesani G,Poli D,Corti M,Mutti A

更新日期：2008-03-01 00:00:00